Fig. 6

Silibinin regulates Aβ processing in APP/PS1 mice. Representative Western blots showing the levels of APP, BACE, IDE, and DEP in the hippocampus of APP/PS1 mice. After 8 weeks of treatment, silibinin significantly decreased the levels of APP and BACE in the hippocampus of APP/PS1 mice. Meanwhile, silibinin 200 mg/kg group significantly increased levels of the NEP protein in the hippocampus. Data are presented as the means ± SEM from four animals per group. ^###p < 0.001 compared with the WT mice; *p < 0.05 and **p < 0.01 compared with the placebo group