Table 3 Half-maximal inactivation voltage (V1/2) and slope (K) of Kv2.1 channels in absence (control) and presence of Lat. B, rapamycin, Lat. B + rapamycin, Lat. B + PIP2 and phalloidin + rapamycin
From: Cytoskeleton disruption affects Kv2.1 channel function and its modulation by PIP2
V1/2 (mV) | K | n | |
|---|---|---|---|
Control | − 31.2 ± 1.1 | 5.7 ± 0.5 | 8 |
Lat. B | − 45.8 ± 1.8*** | 5.9 ± 0.3 | 6 |
Rapamycin | − 44.9 ± 1.7*** | 6.4 ± 0.1* | 7 |
Lat. B + rapamycin | − 46.2 ± 1.9*** | 5.4 ± 0.1 | 10 |
Lat. B + PIP2 | − 46.6 ± 2.8*** | 5.4 ± 0.2 | 5 |
Phalloidin + rapamycin | − 44. 1 ± 1.9*** | 8.8 ± 0.8** | 6 |