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Table 1 Half-maximal inactivation voltage (V1/2) and slope (K) of Kv2.1 channels under whole-cell and inside-out conditions

From: Cytoskeleton disruption affects Kv2.1 channel function and its modulation by PIP2

 

V1/2 (mV)

K

n

Whole-cell

− 27.4 ± 1.2

5.6 ± 0.3

8

Inside-out (1 min)

− 75.2 ± 1.9***

4.8 ± 0.1

6

Inside-out (5 min)

− 86.3 ± 1.8***

6.1 ± 0.23

6

Inside-out (10 min)

− 90.4 ± 1.7***

6.2 ± 0.18*

4

  1. V1/2 and k were calculated by fitting the Boltzmann equation (Eq. 3) to the inactivation curves in each cell/patch
  2. *p < 0.05, ***p < 0.001 versus whole-cell