Fig. 5

Effect of cytoskeleton disruption on the kinetics of Kv2.1 closed-state inactivation. a, b Representative recordings of Kv2.1 currents obtained with a closed-state inactivation protocol (inset) in untreated (control) and Lat. B-treated cells. c Temporal course of closed-state inactivation determined in control conditions (n = 8) and Lat. B-treated cells (n = 7). The data points represent the current evoked by the second depolarizing pulse to + 80 mv, relative to the amplitude of the initial depolarizing pulse, plotted against the duration of the conditioning pulse at − 40 mV. Data are presented as mean ± SEM