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Table 1 Naloxone-induced withdrawal signs in control rats and chronically treated rats with morphine (20 mg/kg, i.p.) daily for seven consecutive days

From: Decrease of inhibitory synaptic currents of locus coeruleus neurons via orexin type 1 receptors in the context of naloxone-induced morphine withdrawal

Withdrawal signs

Control

Morphine-treated

Head moves

1/7

5/7*

Moving paws

0/7

6/7*

Rolling

2/7

4/7

Stretches

1/7

5/7*

  1. Numerators and denominators represent the number of animals expressed morphine withdrawal signs and total number of animals in each group respectively (Fisher’s exact probability test, *P < 0.05, n = 7)
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The Journal of Physiological Sciences

ISSN: 1880-6562

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