Table 1 HR and RRI transfer function and step response parameters obtained from ivabradine protocol

4.32 ± 0.56

4.93 ± 0.55

0.077

0.066 ± 0.005

0.054 ± 0.004

0.072

1.75 ± 0.18

1.59 ± 0.22

0.222

0.77 ± 0.05

0.84 ± 0.07

0.434

3.89 ± 0.49

4.37 ± 0.46

0.510

14.1 ± 0.9

14.8 ± 1.0

0.720

1.38 ± 0.23

2.64 ± 0.32^**

< 0.001

0.066 ± 0.005

0.054 ± 0.005

0.071

1.75 ± 0.19

1.54 ± 0.23

0.272

0.77 ± 0.05

0.85 ± 0.07

0.428

− 1.23 ± 0.18

− 2.40 ± 0.31^*

0.012

14.1 ± 0.9

14.6 ± 1.0

0.767