Fig. 6
Inhibition of adenylyl cyclase enhances the increase in [Ca2+]i induced by Lys-[Des-Arg9]BK in TG neurons. a Example of transient increases in [Ca2+]i during the application of 10 nM Lys-[Des-Arg9]BK (upper white boxes), in the presence or absence of 0.1 μM SQ22536 (upper black box), in the presence of external Ca2+ (2.0 mM). Gray box on the upper-right side of graph indicates an application timing of high-extracellular-K+ (50 mM) solution. b Summary bar graph showing [Ca2+]i increases following the first (upper bar), second (second bar from the top) and third (lowermost bar) application of 10 nM Lys-[Des-Arg9]BK with external Ca2+ (2.0 mM), and following the application of 10 nM Lys-[Des-Arg9]BK with 0.1 μM SQ22536 (third bar from the top). Each bar denotes the mean ± SE of five experiments. Statistical significance between bars (shown by solid lines) is indicated by asterisks: *p < 0.05.