Fig. 6
P2Y2 receptor agonist stimulated HCO3− secretion. Time course and rate of apical HCO3− secretion by control (a, b), 200-ng/ml omeprazole-treated (c, d), and 400-ng/ml omeprazole-treated Caco-2 monolayers (e, f) that were induced by forskolin or MRS2768. Basal (at 20 min; g) and peak forskolin- or MRS2768-stimulated HCO3− secretion (at 33 min; h) by control or omeprazole-exposed Caco-2 monolayers. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the corresponding control group. †P < 0.05, ††P < 0.01, †††P < 0.001 compared with the pre-treated control group (n = 6)