Modulation of Mg2+ influx and cytoplasmic free Mg2+ concentration in rat ventricular myocytes

Table 1 Summary of the initial rate of Mg²⁺ influx obtained at various concentrations of naltriben

Naltriben (μM)	0	2	5	10	20	50
Basal [Mg²⁺]_i (mM)	0.92 ± 0.04	1.02 ± 0.026	0.97 ± 0.02	0.98 ± 0.04	0.94 ± 0.02	0.95 ± 0.04
Initial [Mg²⁺]_i (mM)	0.37 ± 0.01	0.42 ± 0.02	0.34 ± 0.04	0.32 ± 0.04	0.32 ± 0.05	0.36 ± 0.05
Mg²⁺ influx rate (μM/s)	0.22 ± 0.03	0.30 ± 0.07	0.41 ± 0.05**	0.41 ± 0.07*	0.36 ± 0.06*	0.52 ± 0.10**
Number	11	7	10	7	6	9

Basal [Mg²⁺]_i: [Mg²⁺]_i measured just before Mg²⁺ depletion. Initial [Mg²⁺]_i: [Mg²⁺]_i at the beginning of Mg²⁺ recovery (defined as [Mg²⁺]_i at time 0 on the fitted curve). Each data shows mean ± SE from the number (listed in the bottom row) of cells
Statistical differences show **p < 0.01, * 0.01 ≤ p < 0.05 (vs. 0 μM naltriben)

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