Fig. 4
From: Effects of voluntary exercise on antiretroviral therapy-induced neuropathic pain in mice
Voluntary wheel running reduced ddC treatment-induced increase in DRG neuron membrane excitability properties of mice. Whole-cell patch clamp electrophysiology was performed on small-diameter cultured lumbar DRG neurons (n = 3/mouse). a Resting membrane potential was altered by voluntary wheel running (mean ± SEM; n = 10). b Voluntary wheel running reduced AP frequency (mean ± SEM; n = 10) compared to the saline control group (*P < 0.05) and compared to the running/ddC group (# P < 0.05). c Number of spikes was attenuated (mean ± SEM; n = 10) in the no running/ddC group compared to the saline control group (*P < 0.05) and running/ddC group (# P < 0.05). d AP thresholds for generation of APs, obtained by the phase plot analysis of AP (mean ± SEM; n = 10) Significant difference at *P < 0.05 compared to saline and at # P < 0.05 compared to running/ddC group. Bonferroni correction for multiple comparisons