Fig. 6

Role of exercise training in hepatic glucose production. Pyruvate carboxylase protein has shown great importance in hepatic glucose production, modulating the fasting glucose state. Moreover, exercise training can reduce fat accumulation in adipocytes and improve glucose homeostasis. One new mechanism shown in this study is the hepatic PCB content reduction after the exercise training protocol, resulting in better fasting glucose and fasting insulin in obese insulin resistant mice