Fig. 5

Hepatic PCB, gluconeogenic enzymes and Akt phosphorylation of control (CTL), obese (DIO) and trained obese (DIO-EXE) groups. Liver extracts with saline or insulin stimulus. a PCB levels of insulin-stimulated CTL (+) (n = 4) and DIO (+) group (n = 5). b PEPCK levels of insulin-stimulated CTL (+) (n = 4) and DIO (+) group (n = 5). c G6Pase levels of insulin-stimulated CTL (+) (n = 4) and DIO (+) group (n = 5). d p-Akt normalized to total Akt of insulin-stimulated CTL (+) (n = 4) and DIO (+) group (n = 5). e PCB levels of insulin-stimulated DIO (+) (n = 5) and DIO-EXE (+) group (n = 5). f PEPCK levels of insulin-stimulated DIO (+) (n = 5) and DIO-EXE (+) group (n = 5). g G6Pase levels of insulin-stimulated DIO (+) (n = 5) and DIO-EXE (+) group (n = 5). h p-Akt normalized to total Akt of insulin-stimulated DIO (+) (n = 5) and DIO-EXE (+) group (n = 5). Basal = control group for drug administration, used as mechanistic control for insulin injection, not included for statistical analysis. Bars represent means and SEM of 4–5 mice. *p < 0.05 for CTL (+) versus DIO (+); ^# p < 0.05 for DIO (+) versus DIO-EXE (+)