Fig. 6

Trabecular BMD (a), cortical thickness (b), medullary area (c), and representative µCT images of the tibial cortical envelopes (midshaft) (d) of female WT, GK, and GK + Ins rats as determined by in vivo µCT analyses. For the GK + Ins group, rats received daily subcutaneous injection of insulin glargine, while WT and GK rats were injected with normal saline (vehicle). In vivo µCT analyses were performed before insulin treatment (0 week; 8 weeks of age) and at 4, 8, 12 weeks after insulin treatment. Numbers in parentheses are numbers of animals. *P < 0.05, **P < 0.01, ***P < 0.001 vs. age-matched WT rats; ^# P < 0.05 vs. GK rats