Table 1 Highest and lowest scored parameters in β-adrenergic pathway sensitivity analysis
Model outputs | PKA | GSK3β | ERK | CREB | GATA4 |
|---|---|---|---|---|---|
Highest score | \({\text{AF}}\) | \(\left[ {{\text{PP}}2{\text{A}}} \right]\) | \({\text{K}}_{{{\text{Gi}}\beta \gamma :{\text{PI}}3{\text{K}},{\text{iSrc}}}}\) | \(\left[ {{\text{Akt}}_{\text{tot}} } \right]\) | \({\text{K}}_{{{\text{Gi}}\beta \gamma :{\text{PI}}3{\text{K}},{\text{iSrc}}}}\) |
\(\left[ {\text{AC}} \right]\) | \({\text{K}}_{{{\text{m}},{\text{Akt}}:{\text{PIP}}3}}\) | \({\text{K}}_{{{\text{Ras}} - {\text{GDP}}}}\) | \(\left[ {{\text{CREB}}_{\text{tot}} } \right]\) | \({\text{K}}_{{{\text{Ras}} - {\text{GDP}}}}\) | |
\({\text{K}}_{{{\text{act}}1,{\text{Gs}}}}\) | \({\text{K}}_{{{\text{PP}}2{\text{A}},{\text{Akt}}:{\text{PI}}_{\text{p}} }}\) | \(\left[ {{\text{Grb}}2_{\text{tot}} } \right]\) | \({\text{K}}_{{{\text{PDK}}1,{\text{Akt}}:{\text{PIP}}3}} .\left[ {{\text{PDK}}1} \right]\) | \(\left[ {{\text{Grb}}2_{\text{tot}} } \right]\) | |
\(\left[ {{\text{R}}_{{\beta 1{\text{tot}}}} } \right]\) | \({\text{Kr}}_{{{\text{PIP}}3,{\text{Akt}}}}\) | \({\text{K}}_{{{\text{aSrc}},{\text{Shc}}}}\) | \({\text{AF}}\) | \({\text{K}}_{{{\text{aSrc}},{\text{Shc}}}}\) | |
\(\left[ {{\text{PKA}}_{\text{tot}} } \right]\) | \({\text{K}}_{{{\text{hydr}},{\text{PIP}}3}}\) | \({\text{K}}_{{{\text{m}},{\text{aSrc}}}}\) | \(\left[ {\text{AC}} \right]\) | \({\text{K}}_{{{\text{m}},{\text{aSrc}}}}\) | |
Lowest score | \({\text{h}}_{{{\text{AC}},{\text{Gs}}}}\) | \(\left[ {{\text{Akt}}_{\text{tot}} } \right]\) | \(\left[ {{\text{Akt}}_{\text{tot}} } \right]\) | \({\text{h}}_{{{\text{AC}},{\text{Gs}}}}\) | \({\text{V}}_{\text{aSrc}}\) |
\(\left[ {{\text{PDE}}_{\text{tot}} } \right]\) | \({\text{K}}_{{{\text{PDK}}1,{\text{Akt}}:{\text{PIP}}3}} .\left[ {{\text{PDK}}1} \right]\) | \({\text{V}}_{\text{aSrc}}\) | \(\left[ {{\text{PP}}2{\text{A}}} \right]\) | \({\text{V}}_{{{\text{Ras}} - {\text{GTP}}}}\) | |
\({\text{K}}_{\text{PDE}}\) | \({\text{Kf}}_{{{\text{PIP}}3,{\text{Akt}}}}\) | \({\text{V}}_{{{\text{Ras}} - {\text{GTP}}}}\) | \({\text{K}}_{{{\text{m}},{\text{Akt}}:{\text{PIP}}3}}\) | \({\text{V}}_{{{\text{shc}}^{ *} }}\) | |
\({\text{K}}_{{{\text{hydr}},{\text{Gs}}}}\) | \({\text{K}}_{\text{PI}}\) | \({\text{V}}_{{{\text{shc}}^{ *} }}\) | \({\text{K}}_{{{\text{PP}}2{\text{A}},{\text{Akt}}:{\text{PI}}_{\text{p}} }}\) | \({\text{Kr}}_{{{\text{shc}}^{ *} ,{\text{Grb}}2:{\text{Sos}}}}\) | |
\({\text{K}}_{{{\text{m}},{\text{Gs}}}}^{\text{AC}}\) | \(\left[ {{\text{PI}}_{\text{tot}} } \right]\) | \({\text{Kr}}_{{{\text{shc}}^{ *} ,{\text{Grb}}2:{\text{Sos}}}}\) | \(\left[ {{\text{PDE}}_{\text{tot}} } \right]\) | \(\left[ {{\text{Akt}}_{\text{tot}} } \right]\) |