Fig. 5
From: Possible involvement of central oxytocin in cisplatin-induced anorexia in rats
A possible pathway of activated oxytocin (OXT) neurons after peripherally administered cisplatin. Peripherally administered cisplatin activates neurons at the caudal nucleus of the solitary tract (cNTS) via vagus nerve and subsequently activates noradrenaline (NA) neuron at the A1 and A2 area in the medulla. Activated → NA neurons project to OXT neurons in the supraoptic (SON) nucleus and the paraventricular nucleus (PVN). OXT neurons are activated by the autocrine and paracrine system. OXT neurons in the PVN project to the area postrema (AP) and the medial NTS (mNTS), and induced → nausea and vomiting. OXT receptor antagonist (OXTR-A) may block the autocrine and paracrine system in the SON and the PVN, and the projection from the PVN to the AP and the mNTS