Fig. 1

Central A1AR activation combined with cooling induced hypothermia in rats. A typical graph showing changes in body temperature of the rat injected with CHA (20 nmol/head, i.c.v.). The rat was transferred to a cold room kept ambient temperature (T _a) at 4 °C after confirming torpor. Filled circles and open squares show subcutaneous and rectal temperatures, respectively. Rectal temperature was measured by inserting a thermistor into the anus after the rat had been immobilized by hypothermia. Body temperature sequentially decreased and finally reached 15 °C. Similar results were obtained in nine independent experiments (the time required for body temperature to reach 15 °C being 312 ± 88 min)