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Table 9 Phase variables

From: Transmural cellular heterogeneity in myocardial electromechanics

Phase variable

Definition

ENDO

EPI

x r

Coefficient of open probability of the potassium channels for ikr

0.51E−4

1.61E−4

x s

Coefficient of open probability of the potassium channels for iks

0.0659

0.0598

r

Potassium channel activation coefficient for ito

1.78E−8

1.80E−8

s

Potassium channel inactivation coefficient for ito

0.995

0.996

m

Sodium channel activation coefficient

0.0015

0.0016

h

Sodium channel inactivation coefficient

0.9948

0.9948

d

L-channel activation coefficient

2.2E−8

2.2E−8

f

L-channel inactivation coefficient

0.9999

0.9999

f 2,ds

Degree of activation of the L-channels in DS

0.9983

0.9980

[Na+] i (mM)

Intracellular Na+ concentration

4.6423

4.9982

[K+] i (mM)

Intracellular K+ concentration

138.0930

137.7124

[K+] o (mM)

Extracellular K+ concentration

3.9997

4.0019

V (mV)

Membrane potential

−93.208

−93.142

FrAct

Fraction of activated channels

0.00056

0.00205

FrProd

Fraction of inactivated channels

0.22573

0.30025

[Ca2+]up (mM)

Ca2+ concentration in longitudinal reticulum

1.38

1.50

[Ca2+]rel (mM)

Ca2+ concentration in terminal cisterns

1.37

1.49

[Ca2+] i (mM)

Cytosolic Ca2+ concentration

9.2E−6

9.5E−6

[Ca2+]ds (mM)

DS Ca2+ concentration

1.6E−6

2.0E−6

[CaTnC] (mM)

CaTnC concentration

2.3E−4

2.3E−4

[B 1] (mM)

B1 buffer concentration

4.0E−4

4.1E−4

[B 2] (mM)

B2 buffer concentration

9.0E−4

7.2E−4

l 1 (μm)

Deformation of CE relative to the slack length

0.2139

0.2262

l (μm)

Deformation of PE relative to the slack length

0.2139

0.2262

l ex (μm)

Deformation of XSE relative to the slack length

0.0436

0.0313

v (μm/s)

Sarcomere shortening velocity

6.7E−6

0.38E−6

N

Fraction of force-generating Xbs

3.3E−7

0.52E−7