Transmural cellular heterogeneity in myocardial electromechanics

Table 1 Experimental data on the transmural differences in intracellular electrical and mechanical properties between the ENDO and EPI cells taken into account in the cell subtype models

	ENDO	EPI	Animal species	T, °C	Source	Target model parameter	Parameter in the Appendix
Na_v protein expression	Higher	Lower	Guinea pig	4	[1]	Maximum membrane i _pNa conductance	Table 6
i _pNa	Higher	Lower	Dog	37	[43]	Maximum membrane i _pNa conductance	Table 6
i _Kr , i _Ks	Lower	Higher	Guinea pig	35 ± 1	[11]	i _Kr , i _Ks current–voltage parameters	Table 6
i _NaCa	Lower	Higher	Dog	37	[44]	Maximum i _NaK, current	Table 6
i _NaCa	Lower	Higher	Mouse	37	[18]	Maximum i _NaK, current	Table 6
DHP_α1	Higher	Lower	Guinea pig	4	[3]	Membrane permeability for Ca²⁺ through L-type channels, maximum membrane i _bCa conductance	Table 6
Ca²⁺ release from the SR	Lower	Higher	Guinea pig	4	[3]	Sensitivity of the binding sites of ryanodine receptors to the cytosolic Ca²⁺	Table 7
SERCA2	Lower	Higher	Dog	4	[38]	Rate constant of SERCA Ca²⁺ uptake	Table 7
			Guinea pig	4	[3]
			Human	4	[13]
Passive stiffness	Higher	Lower	Guinea pig	26–27	[9]	Scaling coefficient for passive force	Table 8
Passive stiffness	Higher	Lower	Rat, ferret	24–27	[5]	Scaling coefficient for passive force	Table 8
Rate constant of Xb cycling	Lower	Higher	Guinea pig	22	[8]	Rate constant for Xb attachment, Xb attachment-detachment ratio coefficient	Table 8
Rate constant of Xb cycling	Lower	Higher	Pig	22	[7]		Table 8
Ca²⁺ sensitivity of force	Higher	Lower	Guinea pig	22	[8]	Degree of the RU end-to-end cooperativity	Table 8

ISSN: 1880-6562