Fig. 1

Effect of LPS on circadian rhythm of Per2 in mouse liver The quantified data of Per2 at day 1 and day 2 in liver from mice with (b) or without (a) LPS treatment. White and black bars at the top of the figure indicate the time of lights-on and lights-off, respectively. Data are presented as mean ± SEM, n = 3–4, at each time point and analyzed by one-way ANOVA to determine diurnal variations in clock gene expression. Mean expression level of Per2 is shown during day 1 (c) and day 2 (d) in liver from mice with or without LPS treatment. Data are presented as mean ± SEM and analyzed by t test to investigate any differences between control and LPS-treated mice (*P < 0.05, **P < 0.01)