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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes

Fig. 5

Effects of genetic deletion of TRPC3 and TRPC6 on the [Ca2+] transient in cardiomyocytes from 129/Sv mice during the stretch protocol. a Representative traces of the slow increase in [Ca2+] transient during the sustained stretch (SSC) on single cardiomyocytes isolated from 129/Sv wild-type (WT), Trpc3 −/−, and Trpc6 −/− mice. b Summarized data for the stretch-induced change in [Ca2+] transient in cardiomyocytes from WT mice (n = 12). c The stretch-induced slow increase in [Ca2+] transient at 300 s after the stretch (SSC), seen in the WT mice, was suppressed in the Trpc3 −/− and Trpc6 −/− mice (n = 11 and 8). Deletion of TRPC3 and TRPC6 did not affect [Ca2+] transient at initial state and 10 s after the stretch. # P < 0.05 vs initial state; * P < 0.05 vs stretch (10 s). TRPC transient receptor potential canonical, Trpc3 −/− transient receptor potential canonical subtype 3 knockout, Trpc6 −/− transient receptor potential canonical subtype 6 knockout

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