The Journal of Physiological Sciences

Table 1 Effects of CRF and GABA receptor antagonists (or vehicle) on basal 5-HT release in the CeA

From: Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropin releasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus

Treatment	Time (min)
Treatment	−20 to −10	−10 to 0	0–10	10–20	20–30	30–40	40–50	50–60
α-helical CRF (icv)	99 ± 2	100	85 ± 10*	84 ± 5 **	84 ± 6 **	84 ± 7 **	85 ± 7**	83 ± 6**
Vehicle	101 ± 6	100	99 ± 5	99 ± 4	98 ± 6	100 ± 8	100 ± 7	98 ± 9
α-helical CRF (intra-DRN)	99 ± 3	100	100 ± 3	101 ± 7	93 ± 10	98 ± 5	101 ± 10	99 ± 4
Vehicle	99 ± 2	100	100 ± 1	98 ± 3	99 ± 3	96 ± 4	97 ± 2	95 ± 6
Antalarmin (intra-DRN)	100 ± 3	100	101 ± 3	100 ± 6	100 ± 8	105 ± 10	95 ± 8	99 ± 4
Vehicle	101 ± 6	100	101 ± 7	99 ± 3	100 ± 4	101 ± 2	98 ± 4	101 ± 5
ASV-30 (intra-DRN)	100 ± 7	100	101 ± 9	101 ± 4	104 ± 1	101 ± 4	107 ± 5	105 ± 6
Vehicle	103 ± 10	100	98 ± 3	99 ± 3	100 ± 8	97 ± 3	97 ± 5	99 ± 7
Bicuculline (intra-DRN)	101 ± 2	100	109 ± 12	127 ± 11**	122 ± 10**	128 ± 18**	115 ± 16	118 ± 11
Vehicle	101 ± 4	100	101 ± 3	100 ± 5	102 ± 4	98 ± 6	103 ± 14	100 ± 4

0 indicates the onset of administration. Data are expressed as a percentage (mean ± SD) of the pre-injection control value (the value obtained for baseline period of −10 to 0 min)
* p < 0.05, ** p < 0.01, vs. pre-injection control values

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ISSN: 1880-6562

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