Fig. 4

Elevated mitophagy induced by exercise training may be mediated by Bnip3 in mouse skeletal muscle. Representative immunoblot images (a) and densitometric quantification of effects of 8-week swimming training on mitophagy signaling proteins PINK1/Parkin (b, d) and Bnip3 (f). Values are means ± SE; (n = 8) * p < 0.05 vs. sed+sal, ^# p < 0.05 vs. sed+col. ^δ p < 0.05 vs. exe+sal. Expression of PINK1 (c), Parkin (e) or Bnip3 (g) mRNA in triceps muscles of mice was measured following 8-week of swimming exercise training. mRNA levels are relative to the GAPDH (n = 4 per group)