Fig. 4

Effect of EDHB on inflammatory markers in brain. a Pro-inflammatory cytokines (TNF-α, IL-6, IFN-γ) and b MCP-1. c Anti-inflammatory cytokines (IL-10, TGF-β). After hypoxic exposure of 5 h at 9144 m, levels of cytokines in whole brain homogenate were quantified by ELISA. EDHB preconditioning subdued hypoxia mediated proinflammatory cytokine level in brain compared with control. C control, H hypoxia, D drug, DH drug + hypoxia. Values are mean ± SD (n = 8/group). (C vs. H ^a p < 0.01, ^d p < 0.05; H vs. DH ^b p < 0.01, ^c p < 0.05)