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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development

Fig. 5

a Binding partners of FLRT and Unc5 family proteins. FLRT2, -3, Robo4 and Netrin1, -4 are the ligands for Unc5 receptors inducing repulsive responses in cells. FNIII Fibronectin type III domain, LRR leucine-rich repeat domain. b Interaction of FLRT2, -3 with Unc5B, -D on blood vessels and neurons. FLRT2, -3 are cleaved by matrix metalloproteinase (at the site indicated by the scissors). Binding of the ligands to Unc5 receptors normally induces repulsive reactions in tip cells and neurons (color figure online)

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The Journal of Physiological Sciences

ISSN: 1880-6562

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