Fig. 4

Integration of Netrin and Slit1 signaling by rostal thalamocortical axons (rTCAs) at the corridor requires fibronectin leucine-rich transmembrane protein-3 (FLRT3) for proper topographic projection. Schema of a horizontal section of the developing mouse brain showing the topographic distribution of the thalamocortical projections and the gradients from rostral-high to caudal-low of the molecules discussed in the main text: Slit1 and Netrin in the corridor and FLRT3 in the thalamus. rTCAs require high levels of FLRT3 that in combination with Robo1 activates protein kinase A (PKA) signaling and triggers an increase in DCC (deleted in colorectal cancer) levels at the surface of the growth cone to permit the attraction of these axons by Netrin towards the rostral neocortex. iTCAs Intermediate axons. Adapted from Leyva-Díaz et al. [85] (color figure online)