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Fig. 2 | The Journal of Physiological Sciences

Fig. 2

From: A protein tyrosine kinase receptor, c-RET signaling pathway contributes to the enteric neurogenesis induced by a 5-HT4 receptor agonist at an anastomosis after transection of the gut in rodents

Fig. 2

The average number of neurons observed at the anastomosis in the ileum at each of 2 levels of 3 mice in MOS group (n = 6) was significantly larger than that in both the DMSO group (n = 6) (*P < 0.05) and the WA + MOS group (n = 6) (# P < 0.005) for 2 weeks after surgery (A). There was no significant difference in the average number of neurons between the DMSO group and the WA + MOS group. The average number of neurons observed at the anastomosis in the rectum at each of 2 levels of 3 rats in MOS group (n = 6) was significantly larger than that in the DMSO group (n = 6) (*P < 0.01) and in both a 2-indolinone Ret tyrosine kinase inhibitor, RPI-1 + MOS group [local treatment (LT) with RPI-1 (150 µM) + MOS (100 µM)-drinking water rats] (n = 6) and RPI-1 group [local treatment (LT) with RPI-1 (150 µM) rats] (n = 6) (# P < 0.01) for 2 weeks after surgery (B)

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The Journal of Physiological Sciences

ISSN: 1880-6562

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