Table 4 Effects of glibenclamide, 5-hydroxydecanoate, atractyloside, cyclosporin A and diazoxide on cardiac function at pre-ischemia and at 60-min reperfusion in the developing rat
Ventricular function parameters | CON28 | CON28 + GLI | CON28 + 5-HD | CON28 + ATRA | CIHH28 | CIHH28 + CSA | CIHH28 + DIAZ |
|---|---|---|---|---|---|---|---|
LVDP (mmHg) | |||||||
Pre-ischemia | 94.4 ± 2.7 | 96.1 ± 1.0 | 93.2 ± 2.5 | 93.6 ± 1.2 | 96.5 ± 1.1 | 96.1 ± 3.4 | 95.8 ± 4.2 |
Reperfusion | 14.6 ± 2.5 (15.5 ± 2.7) | 12.3 ± 2.7 (12.85 ± 2.9) | 12.1 ± 2.7 (13.0 ± 3.0) | 13.9 ± 2.3 (14.7 ± 2.3) | 26.2 ± 2.6 (27.2 ± 2.7) | 24.6 ± 2.7 (25.9 ± 3.3) | 26.8 ± 2.3 (28.3 ± 3.1) |
LVdp/dt max (mmHg/s) | |||||||
Pre-ischemia | 3322.4 ± 283.1 | 3217.0 ± 131.7 | 3293.9 ± 197.6 | 3248.7 ± 230.7 | 3555.6 ± 324.3 | 3322.3 ± 92.1 | 3434.2 ± 85.1 |
Reperfusion | 288.3 ± 45.2 (8.5 ± 0.7) | 166.0 ± 31.8 (5.2 ± 1.0)* | 203.8 ± 24.0 (6.2 ± 0.6)* | 327.3 ± 45.4 (10.1 ± 1.4) | 655.0 ± 53.1 (18.7 ± 1.9) | 717.9 ± 89.6 (21.5 ± 2.1) | 698.9 ± 63.3 (20.4 ± 2.0) |
Lvdp/dt min (mmHg/s) | |||||||
Pre-ischemia | 2078.4 ± 110.1 | 2168.0 ± 120.0 | 2239.8 ± 242.9 | 2013.9 ± 110.0 | 2375.7 ± 248.2 | 2347.0 ± 214.0 | 2105.9 ± 92.2 |
Reperfusion | 243.9 ± 45.6 (11.7 ± 2.1) | 166.1 ± 39.0 (7.6 ± 1.7) | 208.7 ± 34.4 (9.6 ± 1.7) | 216.5 ± 47.0 (10.7 ± 2.1) | 663.7 ± 115.5 (27.8 ± 3.6) | 606.7 ± 39.9 (26.7 ± 3.6) | 560.7 ± 64.0 (26.7 ± 2.8) |