Ventricular function parameters | Treatment | |||||
---|---|---|---|---|---|---|
Pre-ischemia | Ischemia | Reperfusion–10 min | Reperfusion–20 min | Reperfusion–30 min | Reperfusion–60 min | |
LVDP (mmHg) | ||||||
CON28 | 96.9 ± 3.8 | 0++ | 4.5 ± 1.3++ | 4.0 ± 1.1++ | 9.5 ± 1.6++ | 12.6 ± 3.3++ |
CIHH28 | 96.2 ± 0.6 | 0++ | 12.1 ± 5.1++ | 18.2 ± 6.0++,&&,** | 24.5 ± 6.3++,&&,** | 25.6 ± 3.3++,&&,$,** |
CON42 | 101.5 ± 8.7 | 0++ | 5.6 ± 2.4++ | 7.2 ± 2.6++ | 12.8 ± 2.4++ | 16.6 ± 3.1++ |
CIHH42 | 98.0 ± 4.3 | 0++ | 18.3 ± 4.7++,&,* | 32.5 ± 5.2++,&&,*,# | 41.9 ± 7.4++,&&,$,$,**,## | 46.2 ± 6.6++,&&,$,$,**,## |
LVEDP (mmHg) | ||||||
CON28 | 7.5 ± 0.7 | 72.8 ± 6.6++ | 68.5 ± 4.5++ | 77.2 ± 2.8++ | 76.7 ± 3.5++ | 76.7 ± 3.9++ |
CIHH28 | 5.6 ± 1.0 | 59.2 ± 8.2++ | 67.5 ± 7.2++ | 60.1 ± 7.0++,* | 55.8 ± 6.8++,** | 51.5 ± 6.7++ ** |
CON42 | 7.0 ± 1.2 | 77.3 ± 9.7++ | 78.4 ± 9.2++ | 79.6 ± 6.7++ | 75.3 ± 6.6++ | 76.2 ± 6.4++ |
CIHH42 | 6.2 ± 2.3 | 55.6 ± 6.5++,* | 64.7 ± 4.2++ | 54.5 ± 7.1++,* | 49.4 ± 7.1++,* | 43.3 ± 6.9++,** |
LVdp/dt max (mmHg/s) | ||||||
CON28 | 3478.2 ± 149.7 | 0++ | 234.1 ± 15.1++ | 241.7 ± 20.0++ | 240.0 ± 24.8++ | 246.9 ± 36.9++ |
CIHH28 | 3583.0 ± 205.3 | 0++ | 343.5 ± 45.7++,& | 465.7 ± 38.9++,&&,* | 565.7 ± 36.5++,&&,** | 708.3 ± 57.0++,&&,$,$,** |
CON42 | 3458.3 ± 179.9 | 0++ | 296.3 ± 57.8++ | 353.5 ± 71.2++ | 433.6 ± 81.7++ | 486.4 ± 103.3++,# |
CIHH42 | 3326.9 ± 195.9 | 0++ | 698.5 ± 156.7++,&&,*,# | 841.2 ± 135.7++,&&,*,# | 1180.8 ± 234.6++,&&,**,## | 1383.6 ± 228.4++,&&,$,**,## |
LVdp/dt min (mmHg/s) | ||||||
CON28 | −2270.8 ± 155.7 | 0++ | −221.3 ± 20.5++ | −247.6 ± 20.8++ | −254.5 ± 16.1++ | −242.1 ± 34.1++ |
CIHH28 | −2171.4 ± 103.0 | 0++ | −423.5 ± 114.8++,& | −496.4 ± 161.9++,&&,* | −598.5 ± 145.0++,&&,** | −643.8 ± 111.9++,&&,** |
CON42 | −2156.9 ± 123.3 | 0++ | −284.6 ± 57.4++ | −322.5 ± 59.0++ | −392.8 ± 66.3++,$ | −439.4 ± 92.0++,$ |
CIHH42 | −1992.7 ± 170.6 | 0++ | −242.0 ± 43.4++,& | −542.4 ± 72.2++,&&,* | −699.6 ± 115.6++,&&,$,$,** | −878.7 ± 99.4++,&&,$,$,** |
CF (ml/min) | ||||||
CON28 | 5.8 ± 0.3 | 0++ | 3.4 ± 0.2++,&& | 2.8 ± 0.3++,&& | 2.5 ± 0.3++,&& | 2.1 ± 0.3++,&&,$,$ |
CIHH28 | 7.6 ± 0.2** | 0++ | 4.8 ± 0.3++,&&,** | 4.3 ± 0.4++,&&,** | 3.3 ± 0.2++,&&,$,$,@,* | 3.6 ± 0.4++,&&,$,$,** |
CON42 | 6.4 ± 0.8 | 0++ | 5.0 ± 0.2&&,## | 4.5 ± 0.2++,&&,## | 4.1 ± 0.2++,&&,## | 3.4 ± 0.2++,&&,$,## |
CIHH42 | 11.3 ± 0.4**,## | 0++ | 6.8 ± 0.5++,&&**,## | 6.3 ± 0.5++,&&,**,## | 5.6 ± 0.5++,&&,**,## | 5.0 ± 0.5++,&&,$,$,**,## |