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Table 3 Effect of chronic intermittent hypobaric hypoxia on cardiac function in isolated rat hearts subjected to 30 min of global ischemia followed by 60 min of reperfusion

From: KATP channels and MPTP are involved in the cardioprotection bestowed by chronic intermittent hypobaric hypoxia in the developing rat

Ventricular function parameters

Treatment

Pre-ischemia

Ischemia

Reperfusion–10 min

Reperfusion–20 min

Reperfusion–30 min

Reperfusion–60 min

LVDP (mmHg)

  CON28

96.9 ± 3.8

0++

4.5 ± 1.3++

4.0 ± 1.1++

9.5 ± 1.6++

12.6 ± 3.3++

  CIHH28

96.2 ± 0.6

0++

12.1 ± 5.1++

18.2 ± 6.0++,&&,**

24.5 ± 6.3++,&&,**

25.6 ± 3.3++,&&,$,**

  CON42

101.5 ± 8.7

0++

5.6 ± 2.4++

7.2 ± 2.6++

12.8 ± 2.4++

16.6 ± 3.1++

  CIHH42

98.0 ± 4.3

0++

18.3 ± 4.7++,&,*

32.5 ± 5.2++,&&,*,#

41.9 ± 7.4++,&&,$,$,**,##

46.2 ± 6.6++,&&,$,$,**,##

LVEDP (mmHg)

  CON28

7.5 ± 0.7

72.8 ± 6.6++

68.5 ± 4.5++

77.2 ± 2.8++

76.7 ± 3.5++

76.7 ± 3.9++

  CIHH28

5.6 ± 1.0

59.2 ± 8.2++

67.5 ± 7.2++

60.1 ± 7.0++,*

55.8 ± 6.8++,**

51.5 ± 6.7++ **

  CON42

7.0 ± 1.2

77.3 ± 9.7++

78.4 ± 9.2++

79.6 ± 6.7++

75.3 ± 6.6++

76.2 ± 6.4++

  CIHH42

6.2 ± 2.3

55.6 ± 6.5++,*

64.7 ± 4.2++

54.5 ± 7.1++,*

49.4 ± 7.1++,*

43.3 ± 6.9++,**

LVdp/dt max (mmHg/s)

  CON28

3478.2 ± 149.7

0++

234.1 ± 15.1++

241.7 ± 20.0++

240.0 ± 24.8++

246.9 ± 36.9++

  CIHH28

3583.0 ± 205.3

0++

343.5 ± 45.7++,&

465.7 ± 38.9++,&&,*

565.7 ± 36.5++,&&,**

708.3 ± 57.0++,&&,$,$,**

  CON42

3458.3 ± 179.9

0++

296.3 ± 57.8++

353.5 ± 71.2++

433.6 ± 81.7++

486.4 ± 103.3++,#

  CIHH42

3326.9 ± 195.9

0++

698.5 ± 156.7++,&&,*,#

841.2 ± 135.7++,&&,*,#

1180.8 ± 234.6++,&&,**,##

1383.6 ± 228.4++,&&,$,**,##

LVdp/dt min (mmHg/s)

  CON28

−2270.8 ± 155.7

0++

−221.3 ± 20.5++

−247.6 ± 20.8++

−254.5 ± 16.1++

−242.1 ± 34.1++

  CIHH28

−2171.4 ± 103.0

0++

−423.5 ± 114.8++,&

−496.4 ± 161.9++,&&,*

−598.5 ± 145.0++,&&,**

−643.8 ± 111.9++,&&,**

  CON42

−2156.9 ± 123.3

0++

−284.6 ± 57.4++

−322.5 ± 59.0++

−392.8 ± 66.3++,$

−439.4 ± 92.0++,$

  CIHH42

−1992.7 ± 170.6

0++

−242.0 ± 43.4++,&

−542.4 ± 72.2++,&&,*

−699.6 ± 115.6++,&&,$,$,**

−878.7 ± 99.4++,&&,$,$,**

CF (ml/min)

  CON28

5.8 ± 0.3

0++

3.4 ± 0.2++,&&

2.8 ± 0.3++,&&

2.5 ± 0.3++,&&

2.1 ± 0.3++,&&,$,$

  CIHH28

7.6 ± 0.2**

0++

4.8 ± 0.3++,&&,**

4.3 ± 0.4++,&&,**

3.3 ± 0.2++,&&,$,$,@,*

3.6 ± 0.4++,&&,$,$,**

  CON42

6.4 ± 0.8

0++

5.0 ± 0.2&&,##

4.5 ± 0.2++,&&,##

4.1 ± 0.2++,&&,##

3.4 ± 0.2++,&&,$,##

  CIHH42

11.3 ± 0.4**,##

0++

6.8 ± 0.5++,&&**,##

6.3 ± 0.5++,&&,**,##

5.6 ± 0.5++,&&,**,##

5.0 ± 0.5++,&&,$,$,**,##

  1. * P < 0.05, ** P < 0.01 vs. corresponding CON group; # P < 0.05, ## P < 0.01 vs. CIHH28 or CON28; ++ P < 0.01 vs. corresponding pre-ischemia; & P < 0.05, && P < 0.01 vs. corresponding ischemia–30 min; $ P < 0.05, $ P < 0.01 vs. corresponding reperfusion–10 min; @ P < 0.05 vs. corresponding reperfusion–20 min
  2. Data are expressed as the mean ± SEM (n = 6 per group)
  3. LVDP Left ventricular developing pressure, LVEDP left ventricular end-diastolic pressure, LVdP/dt max maximum rate of rise of left ventricular developed pressure, LVdP/dt min maximum rate of decline of left ventricular developed pressure. CF coronary flow