Fig. 9
From: Luminal trypsin induces enteric nerve-mediated anion secretion in the mouse cecum
Schematic drawing showing the neural loop involved in anion secretion induced by luminal proteases. Modified from Karaki and Kuwahara [57]. See the text and [57] for details. IBD inflammatory bowel disease, IBS irritable bowel syndrome, EC cell enterochromaffin cell, IPAN intrinsic primary afferent neuron, SMN secretomotor neuron, SP substance P, VIP vasoactive intestinal polypeptide. Most of the non-cholinergic secretomotor neurons have been suggested to be VIP-containing neurons [3]