Fig. 4
From: ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway
Blocking ER stress reduced endothelial apoptosis in ABCG1-deficient EC. Compared with control cells (a), endothelial apoptosis was significantly induced in ABCG1-deficient EC (b). c Endothelial apoptosis was partly reversed in ABCG1-deficient EC treated with PBA. d Endothelial apoptosis was moderately but not statistically decreased in control cells treated with PBA. Endothelial apoptosis includes early apoptotic (FITC +PI−) and late apoptotic (FITC +PI+) as described in “Methods”