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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Mechanisms underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea pig ventricular myocytes

Fig. 5

a Time course of channel activity recorded first in the cell-attached (c.a.) mode followed by the inside-out (i.o.) mode. After patch excision, 1 μM CaM + 3 mM ATP was applied to maintain channel activity, then DTNB (1 mM) was added, and finally H2O2 (1 mM) was additionally applied. b Summary of channel activity induced by CaM + ATP + DTNB (n = 5) and CaM + ATP + H2O2 (n = 6), normalized to the activity values obtained for conditions of CaM + ATP. Data are shown as mean ± SE. NS not significant (t test)

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