Fig. 5
From: Elevation of muscle temperature stimulates muscle glucose uptake in vivo and in vitro
AMPK inhibitor partially blocked the heat stimulation-induced muscle glucose uptake in vitro. Isolated extensor digitorum longus muscles of rats weighing ~60 g were pre-incubated without 2-deoxyglucose (2DG) for 30 min at 36 °C either with or without 10 μM compound C (an AMPK inhibitor), 10 μM SB203580 (a p38 MAPK inhibitor), 10 μM KN-93 (a CaMKII inhibitor), or 100 μM NG-monomethyl-l-arginine (L-NMMA; a nitric oxide inhibitor), and then were incubated with 2DG for 10 min at 42 °C. Data are expressed as the mean ± SE (n = 5–8). # p < 0.05 as compared to the control (without the inhibitor). Temp temperature