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Table 1 Relative densities for ionic currents obtained from the literature

From: Contribution of quantitative changes in individual ionic current systems to the embryonic development of ventricular myocytes: a simulation study

 

EE

Reference

LE

Reference

I Na

0.07

[3]

1.00

[3]

I CaL

0.46

[22]

0.78

[2]

I K1

0.11

[36]

1.00

[2]

I Kr

2.0

[16, 17]

2.0

[2, 18]

I KATP

0.32

[3, 37]

0.88

[37, 38]

I to

0.01

[3]

0.27

[38]

  1. The densities relative to that in the adult stage of the Na+ current (I Na), L-type Ca2+ current (I CaL), inward rectifier K+ current (I K1), ATP-sensitive K+ current (I KATP), and transient outward current (I to) for the early embryonic (EE) and late embryonic (LE) stages were estimated from the current–voltage (IV) curves of cells in vitro. The IV curve for I Na was obtained from 11- to 13-day postcoitum (dpc), and 17- to 20-dpc mice [3]. For I CaL, the early embryonic IV curve was obtained from 9.5-dpc mice [22]; the late embryonic IV curve was obtained from 18-dpc mice [22] and fetal guinea pigs 1–7 days before birth [2]. For I K1, IV curves were obtained for the 12-dpc rat [36] and the fetal guinea pig 1–7 days before birth [2]. The relative densities of I KATP were obtained on the basis of the data for the 12-dpc and 18-dpc rats [37]. For I to, IV curves were obtained for 11-dpc mice [3] and 1-day-old rats [38]