Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia–reperfusion injury in rats

Hu, Zhao-Yang; Abbott, Geoffrey W.; Fang, Ya-Dong; Huang, Yue-Sheng; Liu, Jin

doi:10.1007/s12576-013-0261-z

Table 1 Hemodynamics

From: Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia–reperfusion injury in rats

Variable	Baseline	Occlusion	Reperfusion
Variable	Baseline	Occlusion	5 min	30 min	60 min	120 min	180 min
HR (beats/min)
Sham	409 ± 42	400 ± 44^{††,‡‡}	397 ± 40^{††,‡‡}	399 ± 43^{††,‡‡}	391 ± 48^{††,‡‡}	393 ± 41^{††,‡‡}	389 ± 39^{††,‡‡}
CON	435 ± 14	382 ± 18^** ^,##	363 ± 27^** ^,##	361 ± 29^** ^,##	359 ± 27^** ^,##	352 ± 33^** ^,##	318 ± 39^** ^,##
IL	411 ± 42	336 ± 39^* ^,##	319 ± 40^** ^,##	329 ± 43^** ^,##	313 ± 48^** ^,##	302 ± 50^** ^,##	300 ± 43^** ^,##
EIso	422 ± 47	349 ± 37^* ^,##	336 ± 48^** ^,##	319 ± 38^** ^,##	348 ± 50^* ^,#	351 ± 40^** ^,##	332 ± 40^** ^,##
LVSP (mmHg)
Sham	152 ± 7	143 ± 10^{††,‡‡}	145 ± 11^{††,‡‡}	147 ± 8^{††,‡‡}	148 ± 9^{††,‡‡}	148 ± 8^{††,‡‡}	147 ± 9^††,‡
CON	164 ± 7	118 ± 19^** ^,##	113 ± 14^** ^,##	124 ± 15^** ^,##	127 ± 13^** ^,##	128 ± 9^** ^,##	124 ± 20^** ^,##
IL	156 ± 14	115 ± 11^** ^,##	111 ± 11^** ^,##	122 ± 10^** ^,##	122 ± 9^** ^,##	126 ± 12^**, ^##	120 ± 18^** ^,#
EIso	163 ± 6	120 ± 18^** ^,##	113 ± 16^**, ^##	115 ± 9^** ^,##	125 ± 13^**, ^##	129 ± 15^** ^,##	123 ± 16^**, ^##
LVEDP (mmHg)
Sham	−2 ± 2	−1 ± 1^†,‡	−1 ± 1^{††,‡‡}	−2 ± 1^††,‡	−2 ± 1^†,‡‡	−2 ± 1^{††,‡‡}	−2 ± 1^††,‡
CON	−2 ± 2	5 ± 3^** ^,#	5 ± 2^** ^,##	3 ± 2^** ^,#	3 ± 1^** ^,#	4 ± 2^** ^,##	4 ± 1^** ^,##
IL	−1 ± 1	6 ± 2^** ^,#	6 ± 1^** ^,##	3 ± 1^** ^,#	4 ± 2^**, ^##	4 ± 1^** ^,##	4 ± 2^** ^,#
EIso	−1 ± 1	7 ± 2^** ^,##	7 ± 2^**, ^##	6 ± 1^* ^,##	5 ± 4^*, ^#	5 ± 2^** ^,##	4 ± 2^**, ^#
dP/dt _max (mmHg/s)
Sham	6943 ± 732	6354 ± 884^{††,‡‡}	6633 ± 749^{††,‡‡}	6678 ± 757^††,‡	6699 ± 725^{††,‡‡}	6733 ± 685^††,‡	6522 ± 811^{††,‡‡}
CON	7971 ± 858	4748 ± 1064^** ^,##	4342 ± 1115^**, ^##	5066 ± 1239^** ^,##	5492 ± 1437^**, ^##	5811 ± 1378^* ^,##	5054 ± 1322^** ^,##
IL	7039 ± 683	4231 ± 822^** ^,##	3813 ± 691^** ^,##	4618 ± 699^** ^,#	4792 ± 651^**, ^##	5070 ± 784^** ^,#	4359 ± 649^** ^,##
EIso	7877 ± 958	5797 ± 1228^**, ^#	5385 ± 1147^** ^,##	5584 ± 909^** ^,#	6081 ± 996^* ^,##	6176 ± 1004^* ^,##	6118 ± 958^* ^,#
−dP/dt _max (mmHg/s)
Sham	−6634 ± 1998	−5806 ± 1501^†,‡	−6237 ± 1770^{††,‡‡}	−6262 ± 1935^{††,‡‡}	−6318 ± 1895^{††,‡‡}	−6355 ± 1870^††,‡	−6189 ± 1999^††,‡
CON	−7845 ± 1032	−4967 ± 1045^** ^,#	−4871 ± 707^** ^,##	−5277 ± 565^** ^,##	−5294 ± 681^** ^,##	−5355 ± 493^** ^,##	−4492 ± 992^** ^,##
IL	−6786 ± 1429	−3858 ± 632^** ^,#	−3680 ± 847^** ^,##	−4529 ± 1134^**, ^##	−4524 ± 1140^**, ^##	−4704 ± 1155^* ^,#	−4238 ± 1290^**, ^#
EIso	−7096 ± 907	−4291 ± 1754^**, ^#	−4159 ± 1371^**, ^##	−4210 ± 1530^** ^,##	−4733 ± 916^** ^,##	−4882 ± 669^** ^,##	−4649 ± 615^** ^,##

Data are mean values ± SD
LVSP, left ventricular systolic pressure; LVEDP, left ventricular end-diastolic pressure; ±dP/dt _max, maximum rate of increase/decrease in left ventricular pressure. EIso, 2 ml/kg emulsified isoflurane; CON, control; IL, 30 % intralipid. n = 8 in each group
* P < 0.05, ** P < 0.01 vs baseline; ^† P < 0.05, ^†† P < 0.01 vs CON; ^‡ P < 0.05, ^‡‡ P < 0.01 vs IL; ^# P < 0.05, ^## P < 0.01 vs sham

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ISSN: 1880-6562

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