VEGFA SNPs and transcriptional factor binding sites associated with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau

Table 3 Odds ratio (OR), standard error (SE) of the OR, 95 % confidence interval (CI), Chi square and p values for seven VEGFA SNPs in comparison of alleles from the AMS and CMS study groups with their Han (H) and Tibetan (T) control study groups, respectively

SNP	Study group	2n	Alleles		OR^a	SE	95 % CI	Chi square	p value
			A	C
rs699947 (−)2578	AMS (H)	126	29	97	0.803	0.296	0.432–1.494	0.35	0.554
	Normal (H)	118	32	86
	CMS (T)	96	20	76	1.268	0.416	0.524–3.102	0.135	0.713
	Normal (T)	64	11	53
			I	D
rs34357231 rs35569394 (−)2550–2549ins 18 bp I/D	AMS (H)	128	30	98	0.788	0.293	0.427–1.455	0.445	0.505
	Normal (H)	118	33	85
	CMS (T)	96	20	76	1.268	0.416	0.524–3.102	0.135	0.713
	Normal (T)	64	11	53
rs79469752 (−)1203	AMS (H)	104	96	8	0.842	0.628	0.275–2.580	0.005	0.944
	Normal (H)	118	110	8
	CMS (T)	70	63	7	0.509	0.715	0.099–2.342	0.392	0.531
	Normal (T)	56	53	3
			A	G
rs13207351 (−)1190	AMS (H)	96	30	66	0.921	0.298	0.493–1.722	0.016	0.9
	Normal (H)	112	37	75
	CMS (T)	80	20	60	0.733	0.325	0.309–1.745	0.317	0.573
	Normal (T)	48	15	33
			A	C
rs28357093 (−)1179	AMS (H)	106	89	17	0.648	0.396	0.279–1.499	0.819	0.366
	Normal (H)	118	105	13
	CMS (T)	92	82	10
	Normal (T)	58	58
			A	G
rs1570360 (−)1154	AMS (H)	92	18	74	0.973	0.355	0.459–2.060	0	1
	Normal (H)	110	22	88
	CMS (T)	88	11	77	1.4	0.569	0.415-4.962	0.102	0.749
	Normal (T)	54	5	49
			C	G
rs2010963 (−)634	AMS (H)	122	53	69	1.238	0.258	0.724–2.119	0.492	0.483
	Normal (H)	128	49	79
	CMS (T)	94	49	45	0.833	0.332	0.412–1.681	0.148	0.7
	Normal (T)	60	34	26

ISSN: 1880-6562