Fig. 3

Reduction of the high serum (extracellular) Ca²⁺ concentration ([Ca²⁺]_o)-induced Ca²⁺ transient by L-type Ca²⁺ channel inhibitors. The bath contained 2 mM Ca²⁺. a Application of the 3 mM [Ca²⁺]_o solution for 10 s evoked a Ca²⁺ transient (left). Following treatment with 1 µM nicardipine for >25 min, application of the 3 mM [Ca²⁺]_o solution no longer induced a Ca²⁺ transient (right). b In the presence of 0.5 mM Cd²⁺, application of 3 mM [Ca²⁺]_o solution also failed to induce a Ca²⁺ transient (right)