Angiotensin II induced differentially expressed microRNAs in adult rat cardiac fibroblasts

Table 4 The potential target genes of differentially expressed miRNAs in cardiac fibroblasts

miRNA	Potential targets in TargetScan, miRBase	Experimentally validated targets in miRwalk, miRTarBase
miR-125b-3p	ACE, MMP15, MAPK1, MAP2K7, CCNM4, FGFR3, FGF15
miR-132	MMP9, MMP14, MMP16, SPRY1, MAPK3, MAPK13, CDC2a	MMP9, MAP3K3
miR-146b	MMP16, TRAF6, IRAK1, KLF7, KLF4	MMP16, TRAF6, IRAK1
miR-300-5p	Col12a1, FSD1L, Integrin a3, caspase 8, CCND2, CCNB1, CCNK, CCNT2, CCNM4, CCNA2, CDK1	TGFBR1, caspase 8
miR-181b	Col7a1, Col16a1, Integrin a2, a3, a6, b8, elastin, TIMP2, TIMP3, IL1a, IL6, TGFBR3, TGFa, MAP3K6, MAP3K10	TIMP3, IL1a

ACE angiotensin-converting enzyme, MMP matrix metalloproteinases, MAPK mitogen-activated protein kinase, FGFR3 fibroblast growth factor receptor 3, FGF15 fibroblast growth factor 15, SPRY1 sprouty homolog 1, CDC2a Cdk1(cyclin-dependent kinase 1), TRAF6 TNF receptor-associated factor 6, IRAK1 interleukin-1 receptor-associated kinase, KLF7(4) Kruppel-like factor 7 (4), Col12a1 collagen, type XII, alpha 1, CCND2 cyclin D2, CCNB1 cyclin B1, CCNK cyclin K, CCNT2 cyclin T2, CCNM4 cyclin M4, CCNA2 cyclin A2, Col7a1 collagen, type VII, alpha 1, Col16a1 collagen, type XVI, alpha 1, IL1a interleukin 1, alpha, TGFBR3 transforming growth factor, beta receptor III, TIMP tissue inhibitors of matrix metalloproteinases

ISSN: 1880-6562