Fig. 1
From: Effects of the AMP-activated protein kinase inhibitor compound C on the postconditioned rat heart
Effects of compound C (CC) on a rate-pressure product (RPP), b peak rate of contraction (+dP/dt), c peak rate of relaxation (−dP/dt), d left ventricular end-diastolic pressure (LVEDP) due to ischemia–reperfusion in control and postconditioned hearts. Values are expressed as a percentage of the respective basal value at the end of the 25-min equilibration period. Squares control hearts. Circles postconditioned hearts. Filled symbols hearts perfused with CC added to the perfusion medium during the first 5 min of reperfusion. Open symbols hearts perfused in the absence of CC. Ischemic postconditioning was induced by six cycles of 10-s reperfusion interspersed with 10-s no-flow ischemia immediately after sustained ischemia. Values are mean ± SEM (n = 8). *p < 0.05 versus all other groups