Fig. 5

Rapid cooling-induced Ca²⁺ release in the presence or absence of ATP. a, b Traces show changes in solution temperature (top) and [Fluo-3-Ca] (bottom) in the presence (a) or absence (b) of ATP. The fluorescence recording was terminated by closing an optical shutter at the times indicated by arrows. c Summary of RC-induced Ca²⁺ release (Δ[Fluo-3-Ca]) estimated in the type of experiments shown in a and b. Left and right columns represent mean ± SEM of data obtained, respectively, in the presence (n = 16) and in the absence (n = 7) of ATP