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Table 1 Effects of IPC and chelerythrine on GSH and MDA levels following hepatic I/R

From: Differential consequences of protein kinase C activation during early and late hepatic ischemic preconditioning

Group

GSH (μmol/g liver)

MDA (nmol/mg protein)

3 h

24 h

3 h

24 h

Sham

7.2 ± 0.6

7.2 ± 0.7

0.3 ± 0.0

0.3 ± 0.0

I/R

2.8 ± 0.5**

4.9 ± 0.5

0.6 ± 0.0**

0.7 ± 0.1**

IPC + I/R

5.0 ± 0.5*,+

5.6 ± 0.7

0.4 ± 0.0*,+

0.6 ± 0.1**

CHE + IPC + I/R

2.4 ± 0.4**,##

4.1 ± 0.3*

0.7 ± 0.1**,##

0.6 ± 0.1**

  1. The levels of GSH and MDA were determined at 3 h and 24 h after reperfusion. Results are presented as mean ± SEM of sham, 3 h (n = 8); I/R, 3 h (n = 9); IPC + I/R, 3 h (n = 10); CHE + IPC + I/R, 3 h (n = 10); sham, 24 h (n = 8); I/R, 24 h (n = 9); IPC + I/R, 24 h (n = 10); CHE + IPC + I/R, 24 h (n = 10)
  2. GSH glutathione, MDA malondialdehyde, I/R ischemia and reperfusion, IPC ischemic preconditioning, CHE chelerythrine
  3. *,**Significantly different (P < 0.05, P < 0.01) from sham
  4. +Significantly different (P < 0.05) from I/R
  5. ##Significantly different from IPC + I/R
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The Journal of Physiological Sciences

ISSN: 1880-6562

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