Fig. 5

Effect of inhibitors of arachidonic acid metabolism on I _sc induced by 100 nM serosal trypsin. Indomethacin (10 μM) was added to both the mucosal and serosal sides, and NDGA (50 μM) and SKF-525A (30 μM) were each added to the serosal side 20 min before adding trypsin (100 nM) to the serosal side. Each data value is presented as the mean ± SE, with n = 5. ***P < 0.001, compared with the control response that had been determined in the adjacent tissue by a paired t test