Table 2 Basic properties of LOs
From: Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension
Gene name | Alternative nomenclature | Predominant enzyme products | Main distribution |
|---|---|---|---|
ALOX15 | 15-LOX-1 | 15(S)-HPETE, 15(S)-HETE | Reticulocyte, eosinophils, bronchial epithelial cells |
15-LOX-2 | 15(S)-HPETE, 15(S)-HETE | Prostate, skin, lung, cornea | |
ALOX12 | Platelet-type lipoxygenase 12 | 12(S)-HPETE, 12(S)-HETE | In various cell types |
Epidermis-type lipoxygenase 12 | 12(R)-HPETE, 12(R)-HETE | In various cell types | |
Leukocyte-type lipoxygenase 12 | 12(S)-HPETE, 12(S)-HETE | In various cell types | |
ALOX8 | 8-LOX | 8(S)-HPETE, 8(S)-HETE | Only in mice and rats tissues |
ALOX5 | 5-LOX | 5-HETE, leukotrienes | In various cell types |