Fig. 5

Simplified gating models of thymocyte Kv1.3-channels. A three-state gating model in 500-ms pulse protocols (A) and two-state gating models in 10-ms pulse protocols (B). The composite states are C (closed), O (open) and I (inactivated). The transitions “C → O”, “O → I” and “I → C” represent the activation, the inactivation and the recovery from the inactivated-state, respectively. Circled arrows represent accelerated transitions