Fig. 4

Effects of chloroquine on the activation and the inactivation kinetics of thymocyte Kv1.3-channel currents. Effects of 10 µM chloroquine on the current density–voltage relationship (A a), the activation curve (A b) and the inactivation curve (B). A Pulses were applied for 10 ms from the holding potential of −80 to +80 mV in 20-mV increments, while in B, a test pulse to +80 mV was applied for 20 ms following 500-ms pre-pulses from −80 to 80 mV in 40-mV increments. They are depicted in the voltage protocols in A a and B, respectively. Each point represents the mean ± SEM (n = 6)