Long-term blood pressure control: is there a set-point in the brain?

Table 2 Pioneering process for endothelial regulation of vascular smooth muscle activity, called as Local Control

1956	Renin-like enzyme in vascular wall [49]
1971	Brain renin–angiotensin system [50, 51]
1976	Tissue renin–angiotensin system [52]
1984	Vascular renin–angiotensin system [53, 54]
1987	‘‘Vascular RAS is still doubtful’’ [55]
1988	Local generation of vascular Ang II [56]
1990	Chymase in human heart [57]
1990	Overexpression of human chymase in rat vessels produces hypertension [58]
1976	PGI2, Prostacyclin [59]
1980	EDRF [60]
1987	NO, NOS (Ignarro, Palmer, Moncada)
1998	Nobel Prize Award
1988	Endothelin [61]
1990	CNP C-type natriuretic peptide [62]

ISSN: 1880-6562