Fig. 8
From: Differential effects of acute hypoxia on the activation of TRPV1 by capsaicin and acidic pH
A schematic model for the O2-dependent modulation of TRPV1 activity. Hypothetical dual effects of ROS on TRPV1 at the extracellular and intracellular sides of the plasma membrane are proposed. Hypoxia might increase intracellular ROS via a putative mitochondria-dependent manner. The activation by capsaicin might be hindered by hypoxia per se or by intracellular ROS-dependent oxidation