Fig. 3
From: Differential effects of acute hypoxia on the activation of TRPV1 by capsaicin and acidic pH
No effect of hypoxia on acidic pH-activated TRPV1 current (I TRPV1,Acid). a Representative current trace at −20 mV holding voltage showing the response to acidic condition (pH 6.2) in GFP-only (left) and TRPV1 + GFP-expressed (right) HEK293T cells. A transient inward current was induced by the acidic pH in both cell groups whereas a sustained inward current was additionally observed in the TRPV1-expressed cells. The pH-activated transient current was abolished by 30 μM amiloride, a blocker of ASIC (see inset). b TRPV1 was repetitively activated by acidic pH, and hypoxia (\( {\text{P}}_{{{\text{O}}_{2} }} \) 3%) was applied between the third and the fourth application of pH 6.2. c Summary of the inward currents normalized to the first response (n = 20)