Fig. 2
Intracellular calcium transient Cai (a), myocardial tension (b), sarcomere shortening (c), and ATP consumption rate (d) as obtained from simulations with normal and HF models. The calcium transient is normalized by the peak calcium concentration under normal conditions. Sarcomere length is normalized by its value in the isometric contraction phase. The ATP consumption rate is normalized by the peak ATP consumption rate under normal conditions. HF denotes a heart failure patient