Endothelin-induced changes in blood flow in STZ-diabetic and non-diabetic rats: relation to nitric oxide synthase and cyclooxygenase inhibition

Table 1 Local blood flow in the examined tissues under resting condition before endothelin-1 administration in normal and STZ-diabetic rats

Tissue (unit)	Type of rat	Blood flow No pretreatment normal (n = 7), STZ (n = 5)	Blood flow L-NAME pretreated normal (n = 8), STZ (n = 6)	Blood flow indomethacin pretreated normal (n = 5), STZ (n = 5)
Right kidney [g/min/g(tw)]	Normal	5.8 ± 0.3*	2.3 ± 0.3	6.1 ± 0.3
Right kidney [g/min/g(tw)]	STZ	4.0 ± 0.4	2.7 ± 0.1	3.3 ± 0.4
Left kidney [g/min/g(tw)]	Normal	5.7 ± 0.3*	2.3 ± 0.2	5.7 ± 0.3
Left kidney [g/min/g(tw)]	STZ	3.9 ± 0.4	2.5 ± 0.1	3.1 ± 0.5
Heart [g/min/g(tw)]	Normal	4.2 ± 0.4	2.8 ± 0.2*	4.8 ± 0.5
Heart [g/min/g(tw)]	STZ	3.6 ± 0.4	2.2 ± 0.1	3.6 ± 0.4
Skeletal muscle [g/min/g(tw)]	Normal	0.16 ± 0.03	0.06 ± 0.01*	0.13 ± 0.04
Skeletal muscle [g/min/g(tw)]	STZ	0.15 ± 0.03	0.12 ± 0.02	0.13 ± 0.05
Choroid (mg/min)	Normal	59 ± 14	6 ± 2	47 ± 15
Choroid (mg/min)	STZ	45 ± 6	10 ± 3	52 ± 12
Anterior uvea (mg/min)	Normal	49 ± 6	16 ± 2	48 ± 7
Anterior uvea (mg/min)	STZ	38 ± 2	18 ± 2	41 ± 6
Retina (mg/min)	Normal	2 ± 1	2 ± 1	3 ± 1
Retina (mg/min)	STZ	4 ± 1	2 ± 1	1 ± 1
Brain (left hemisphere) [g/min/g(tw)]	Normal	0.84 ± 0.07
Brain (left hemisphere) [g/min/g(tw)]	STZ	0.80 ± 0.07

Data are the mean ± SEM. Mann–Whitney U test between groups
STZ Streptozotocin, L-NAME a NO synthase inhibitor, Indomethacin a cyclooxygenase inhibitor
* P < 0.05

ISSN: 1880-6562