Fig. 3

Endothelin-1 (ET-1)-induced effects on blood flow in different organs, ET-1 alone (black columns), ET-1 with L-NAME (gray columns), and ET-1 with indomethacin (white columns). Data presented as % change from baseline. a Normal SpD-rats and b diabetic rats (SpD-STZ). Data are the mean ± SEM. Asterisk above column shows significance at P < 0.05 regarding change in blood flow compared to baseline within each group of animals